Neuroprotective agent under trial for PD

Coenzyme Q-10
Ginko Biloba
NMDA antagonists
MAO-B inhibitors
Vitamin c and E
Steroids
Cox2 inhibitors
Anti apoptotic agents
Dopamine agonists

Metabolic causes of acute dystonia and chorea

Hyperthyyroidism
Hypocalcemia
Hypoglycemia
Hyperglycemia
Hypernatremia
Hyponatremia
Hypomagnesemia
Splenorenal shunt
Osmotic demyelination

DRUGS that can cause acute dystonic reaction(EPS)

Neuroleptics
Dopamine agonists
Anticonvulsants like phenytoin,carbamazepine,phenobarbitone,ethosuxemide ,valproate
Trycyclic anti depressants
Calcium channel blockers
Diazepam
Domperidone
Inderal
Chloroxazone

Use of bitulinum toxin in children

Botulinum toxin (BOTOX) is used in the treatment of spasticity in children.Doses of up to 29 units per kilogram has been used in some studies.Body weight,muscle size,location of muscle and degree of spasticity has to be considered in selecting the dosages.However there are no studies to indicate how much dose should be used to saturate neuromuscular junction is unknown.botox when injected will diffuse into the muscle and block the nearby neuromuscular junction.This causes defective acetylcholine release.increasing the amount of saline used for dilution increase the diffusion.Local anaesthetic may be required before injecting botox in children.